VI Agglutinative Properties for Bacterium typhosum demonstrated following Infection with Malaria, Parasites.

Abstract

Abstract Vi agglutinative properties were demonstrated with typhoid bacilli in significant dilutions of sera from (1) twenty-three of thirty-four patients having neurosyphilis or latent syphilis and who were receiving malarial therapy; (2) two of ninety-six individuals who had received no malarial therapy; (3) eleven of twenty-eight patients with clinical malaria; and (4) fourteen of thirty-one neurosyphilitic patients who had been treated by intravenous injection of typhoid vaccine. Two hypotheses are offered: (1) that malaria parasites possess Vi antigen and (2) that latent agglutinative properties are stimulated. These observations should be considered in evaluating Vi agglutination. A continuation of the study should include the examination of various species of bacteria for Vi antigen and the determination of factors that may stimulate latent Vi agglutinative properties.