Abstract
This study presents a chemically modified molecular motor designed for interactions with lipid bilayers. By incorporating long alkyl chains into the anchoring fragment and a rhodamine luminescent tag onto the rotating subunit, we aim to monitor the position of the motor and allow for its real-time visualization during membrane perforation experiments. The synthesis of the functionalized tripodal ligand involved a seven-step process, culminating in the formation of a piano-stool Ru(II) complex that exhibits distinctive spectroscopic properties. The luminescence of the rhodamine tag, while slightly quenched upon incorporation in the Ru(II) complex, remains sufficiently strong to enable the single-molecule observation using a total internal reflection fluorescence (TIRF) microscope.
Published Version
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