Abstract
Pharmacology β-Amyloid deposits in the brain are a hallmark of Alzheimer's disease. The binding of β-amyloid to the metabotropic glutamate receptor mGluR5 contributes to disease progression. Abd-Elrahman et al. found that β-amyloid was bound to mGluR5 in brain tissue samples only from male Alzheimer's disease model mice or male patients. Blocking the activity of mGluR5 reversed cognitive decline in male mice but not in their female counterparts, suggesting that mGluR5 inhibitors may be therapeutically beneficial only for male Alzheimer's disease patients. Sci. Signal. 13 , eabd2494 (2020).
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