Abstract
An aggregation-induced emission (AIE)-featured triphenyltin (IV)-acylhydrazone compound (SnTPA) was designed and characterized. SnTPA exhibited a pronounced fluorescence enhancement in the aggregate state with an absolute fluorescence quantum yield of 12.6% and blue–green emission. A series of experiments confirmed that the restricted intramolecular rotation (RIR) was the main mechanism of AIE for SnTPA. Owing to the suitable fluorescence, confocal laser detection revealed that SnTPA could accumulate in the lysosomes of A549 cells (lung cancer), leading to damage to lysosomal integrity and eventually inducing cell death. Flow cytometry confirmed that SnTPA could block cell cycle progression (S phase), induce the accumulation of intracellular reactive oxygen species (ROS), and realize apoptosis. In addition to displaying good anticancer activity (similar to cis-platin), SnTPA could also inhibit the migration of A549 cancer cells. Therefore, SnTPA can be used as an effective fluorescent organometallic targeted anticancer drug for further study.
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