An advanced decellularized dermis intended for soft tissue repair: A new surgical approach for DFU

Abstract

Skin substitutes are heterogeneous group of biological and/or synthetic elements that enable the temporary or permanent occlusion of wounds. Although dermal substitutes can vary from skin xenografts or allografts to a combination of autologous keratinocytes over the dermal matrix, their common objective is to achieve the greatest possible similarity with the patient’s skin The acellular dermal matrix allows the body to rebuild its own strong tissue without the need for alloplastic material. The three-dimensional collagen will be replaced by vital new tissue. An alternative treatment for diabetic foot ulcers is a matrix scaffold for new tissue generation, an acellular human dermal matrix (ADM) allograft. Decellularized human skin has been used for a variety of medical procedures, primarily involving wound healing, soft tissue reconstruction, and sports medicine applications.