Amyloid transfer from a syngeneic graft of amyloid spleen in intact and amyloid mice

Abstract

The investigation was carried out on male CBA mice using the casein model of amyloidosis. After simultaneous transplantation of fragments of spleen from intact and amyloid donors beneath the capsule of opposite poles of the kidney into intact and amyloid recipients, deposits of amyloid both in the endogenous spleen and in the graft from intact donors were found in 40% of intact animals. In amyloid recipients under observation for periods of between 5 days and 6 months, deposits of amyloid in the intact graft were observed in only 5% of cases. It is postulated that amyloidosis is “transferred” through migration of cells participating in amyloid formation and that this mechanism is inhibited in animals with amyloidosis.