Abstract
Studies with the polarizing microscope on 13 mouse adenocarcinomas have shown that all contain amyloid deposits. Much of the amyloid appears in the tumor stroma where it is formed into fibril bundles sometimes condensed into complexes. Stromal histiocytes are typically associated with strongly birefringent areas but the same is not true of stromal fibroblasts. Intracellular birefringence was sometimes seen within the parenchymal epithelium and stromal macrophages. There are numerous examples of degenerating carcinomatous tubules whose lumina contain amyloid deposits which are fibrillar or diffuse in character. Presumably, such deposits were secreted by the surrounding epithelial cells. It is suggested that polarizing microscopic studies on other types of tumors may reveal that the presence of amyloid deposits is relatively common.
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