Abstract
In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete Amycolatopsis sp. WP1, yielded six novel amycolachromones A–F (1–6), together with five known analogues (7–11). Amycolachromones A–B (1–2) possessed unique dimer skeletons. The structures and relative configurations of compounds 1–11 were elucidated by extensive spectroscopic data analyses combined with X-ray crystal diffraction analysis. Plausible biogenetic pathways of amycolachromones A–F were also proposed.
Highlights
Marine microbial natural products, especially those derived from marine actinomycetes, have become an important source of novel bioactive compounds [1,2,3]
Various strategies have been proposed to activate the expression of otherwise silent biosynthetic gene clusters, including the ‘one strain many compounds’ (OSMAC) approach [7], co-cultivation with other microorganisms [8] and chemical epigenetics [9]
A ribosome engineering approach that targets ribosomal proteins or RNA polymerase (RNAP) has shown promise for expression of cryptic gene clusters. This method selects for mutants that are resistant to antibiotics that target the bacterial ribosome, presumably activating the expression of bacterial cryptic genes by resistant mutants [10,11]
Summary
Especially those derived from marine actinomycetes, have become an important source of novel bioactive compounds [1,2,3].
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