Amplitude of Low-Frequency Oscillations in First-Episode Drug-Naive Patients with Major Depressive Disorder: A Resting State Functional Magnetic Resonance Imaging Study.

Abstract

ObjectiveTo observe characteristics of the amplitudes of low-frequency oscillation (LFO) in first-episode drug-naive patients with major depressive disorder (MDD).MethodsAmplitudes of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were computed using resting-state functional magnetic resonance imaging (rs-fMRI) data of 39 first-episode drug-naive patients with MDD and 37 healthy controls.ResultsALFF and fALFF in the left cerebellum were significantly higher in patients with MDD compared to control group, while ALFF in the right rolandic operculum was significantly lower (all p < 0.001, AlphaSim correction).ConclusionAbnormal neurological activity in multiple brain regions in first-episode drug-naive patients with MDD may be involved in the neurobiological mechanisms of MDD and should be considered in future studies.