Resting state functional magnetic resonance imaging in patients with first-episode major depression disorder

Abstract

Objective To explore the abnormally functional brain region in resting state in first-episode major depression disorder patients with function magnetic resonance imaging. Methods 51 patients diagnosed with first-episode major depression disorder according to DSM-Ⅳ and 50 gender-, age-, and education-matched healthy controls completed resting state fMRI scan. The severity of depression, and unpredicted homodynamic responses across the whole brain were analyzed using Hamilton depression scale, regional homogeneity and amplitude of low-frequency fluctuation, respectively. Results Compared with control group, the right medial frontal gyrus(BA6, MNI: 3, -3, 63, K=34) and left medial frontal gyrus(BA9, MNI: -9, 36, 30, K=10)(P<0.001, uncorrected)in the case group showed higher regional homogeneity , with statistical significance.Compared with control group, right medial frontal gyrus(BA6, MNI: 3, -3, 63, K=35) and right posterior cingulated gyrus (BA31, MNI: 3, -36, 36, K=11)(P<0.001, uncorrected)in the case group showed higher amplitude of low-frequency fluctuation, with statistical significance. Conclusion First-episode major depression disorder patients in resting state had several abnormally functional brain regions, which might be related to the pathological mechanism of depression disorder. Key words: Depression disorder; Function magnetic resonance imaging; Restingstate; Regional homogeneity; Amplitude of low-frequency fluctuation; Default mode network