Abstract
A newly synthesized polyfluorene derivative with pendant di(2-picolyl)amine (PF-DPA) shows dual state emission and aggregation caused red shifted emission that was utilized for cell imaging and cancer theranostics. PF-DPA was nontoxic to normal cells but showed cytotoxicity against cancer cells, suggesting its utility for cancer therapy. PF-DPA exhibits a large and unique red shifted emission at 556 nm at higher water ratio of THF:H2O (10:90) due to the formation of polymer nanoparticles or PDots spontaneously by intra- and intermolecular self-assembly induced aggregation. Dual state emission and aggregation caused red shifted emission (>100 nm) in PF-DPA homopolymer nanoparticles is very unique and attributed to the combined effect of intramolecular planarization and J-type aggregate formation in the PDots (25 ± 5 nm). The PF-DPA PDots exhibit bright green and orange fluorescence with exceptional live cell imaging properties and potential applications in cancer theranostics due to their selective cytotoxic nature toward cancer cells.
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