Amplification or Controlling Genes in Cell Mediated Lympholysis

Abstract

The development of cell-mediated lympholysis in the mouse depends on H-2 incompatibility and the MHS controls both the antigens, which serve as targets for destruction and the determinants involved in the generation of effectors. The genes that control the generation of effectors for chronic myelogenous leukemia (CML) are different from the genes that make the targets for destruction in CML testing. Genes controlling the generation of effector capacity are found in the I region of the H-2 gene complex close to but separate from the strong leukocyte adhesion deficiency (LAD) genes. The chapter describes the mapping of the area concerned, called the effector cells stimulating (ECS), carried out using 20 congenic and recombinant mouse strains. This is now been extended to 39 strain combinations. ECS amplification acts on the target cells and is the major genetic factor in the control of antigenic strength as applied to cell-mediated lympholysis.