Abstract
1. 1. Ampicillin concentrations in serum ( n = 20), gingiva ( n = 12), jawbone ( n = 13), dental follicle ( n = 12), radicular granuloma ( n = 2) and radicular cyst ( n = 2) were measured in specimens obtained during 0.5–2.5 hr after a single oral administration of lenampicillin (equivalent to 500 mg of ampicillin). 2. 2. Measurable ampicillin concentrations were found in all serum and tissues. 3. 3. Ampicillin concentrations in serum and tissues except for some gingiva and jawbone exceeded MIC for 90% of clinically isolated strains of alpha-hemolytic Streptococci. 4. 4. Ampicillin concentrations in gingiva and jawbone were below the MIC for 90% in 2 out of 12 and 4 out of 13 specimens, respectively.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call