Abstract
Background Amphicrine carcinomas are a rare subgroup of mixed adenoneuroendocrine carcinomas (MANECs) in which tumour cells show evidence of both glandular and endocrine differentiation. Methods We present a case of caecal amphicrine carcinoma in a 76-year-old woman. She developed metastatic peritoneal disease 2 months after her right hemicolectomy. Light microscopy and immunohistochemical findings with regard to diagnostic and prognostic factors are described and the literature is reviewed. Conclusion Mixed exocrine-neuroendocrine neoplasms, now renamed as mixed adenoneuroendocrine carcinomas (MANECs) are, by definition, neoplasms in which each component represents at least 30% of the lesion. In apmhicrine tumours, first described by Feyrter (1938), exocrine and neuroendocrine features are co-expressed by same neoplastic cells. There has not been a consistent classification system of these tumours for many decades. Following the recent WHO classification of neuroendocrine tumours of digestive system (2010), Rosa et al . divided MANECs into two groups: high and intermediate grade malignant neoplasms. They classified amphicrine carcinomas as intermediate grade malignancies. The optimal strategy of management of MANECs is largely unknown, due to rarity of these neoplasms. The adaptation of a consistent classification system is the first step in gathering more accurate prognostic data and evaluating treatment options.
Published Version
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