Abstract
This study is intended to ascertain whether SNPs in genes NTRK2 and BDNF , life events, as well as baseline cognitive and neuroendocrine measures can predict antidepressant treatment in Han Chinese people. We conducted a case-control study by 354 patients with major depressive disorder (MDD).We found NTRK2 -rs720141 polymorphism was significantly associated with antidepressant response. The scores of negative life events were higher in non-responders than responders. In the cognitive model, only the deficit in working memory as measured by Wisconsin Card Sorting Test (WCST) could identify treatment. We failed to detect any association between neuroendocrine parameters and antidepressant response. By using logistic regression, we found that a main effect on predicting treatment response was apparent for rs720141 genotype, deficit in working memory and the scores of negative life events. The combination of the three factors revealed the 74.8% explanation for the variance. Our research will be a new method for prediction of antidepressant treatment outcome.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call