Abstract
Balanites aegyptiaca (L.) Del. (Balanitaceae), a tropical plant is well known for its widespread uses in Burkina Faso traditional medicine. The present study aims to evaluate the anti-inflammatory effect of B. aegyptiaca trough the turpentine-induced inflammation. The aqueous acetone extracts of galls and leaves have been used to test the anti-inflammatory effects on adult male Wistar-Bratislava albino rats. Total leukocytes count was performed with an optical microscope (Olympus), using a Burcker-Turk counting-chamber. The nitric oxides synthesis (NOx), the total oxidative status (TOS) and total antioxidant response (TAR) of the serum were measured using a colorimetric assay. The results have showed that all the extracts reduced significantly (p<0.0001) the total leukocytes and total nitrites and nitrates levels in the rats serum. The oxidative stress evaluation showed that the treatment with any dose of B. aegyptiaca gall and leaf extracts was significantly decreased (p<0.0001) the total oxidative status. Moreover, these extracts have been prevented the Turpentine oil induced inflammation by increasing the total antioxidant response. TAR increasing did correlated to TOS decrease by comparison with the inflammation group. In general, an interesting anti-inflammatory effect was found in this study with the greatest activity found in the gall extracts. B. aegyptiaca could then be a potential source of natural antioxidants and anti-inflammatories.
Highlights
Balanites aegyptiaca (L.) Del. (B. aegyptiaca), known as ‘Desert date’ in English is one of the most common but neglected wild plant species of the dry land areas of Africa and South Asia [1]
The base-line characteristics presented in Figure 1 show that the turpentine-induced inflammation group had a significantly higher number of total leukocytes count (Figure 1(a)) and higher rate of nitric oxides synthesis (NOx) in the serum (figure 1(b)) compared to the control and treated groups (p
The present study aims to evaluate the anti-inflammatory activities of B. aegyptiaca gall and leaf extracts trough the mechanism involving the inhibition of total leukocytes and the reduction of NOx rate in the serum and the oxidative stress parameters via the measurement of the serum total oxidative status (TOS) and total antioxidant response (TAR) from each individual rat
Summary
Balanites aegyptiaca (L.) Del. (B. aegyptiaca), known as ‘Desert date’ in English is one of the most common but neglected wild plant species of the dry land areas of Africa and South Asia [1]. (B. aegyptiaca), known as ‘Desert date’ in English is one of the most common but neglected wild plant species of the dry land areas of Africa and South Asia [1]. Different parts of this plant are traditional used in several African folk medicines [2,3,4]. Literature has revealed that the barks are anthelmintic [5], the leaves and galls have antibacterial properties [6] and the fruits are effective against Aedes aegypti larvae [7, 8]. Anti-inflammatory activities of the aerial part from B. aegyptiaca have been demonstrated using the carrageenin-induced edema in the rat method [11]
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