Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy.

Adriana Florinela Cӑtoi,Aurel Mironiuc,Alina Elena Pârvu,Ioana Delia Pop,Ştefan Chiorescu,Alexandra Crӑciun,Cornel Cӑtoi

doi:10.1155/2018/1583212

Abstract

Background Chemerin is a chemokine known to be increased in morbidly obese (MO) patients and correlated with markers of inflammation and nitrooxidative stress. We aimed to evaluate the changes of serum chemerin six months after laparoscopic sleeve gastrectomy (SG) and to asses if these changes are accompanied by variations of inflammatory and nitrooxidative stress markers. Material and Methods We investigated the levels of chemerin, high-sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), and oxidative stress index (OSI) in a group of 24 MO patients submitted to SG before and six months after surgery. The MO group was compared with 20 controls. Results hsCRP (p < 0.001), NOx (p < 0.001), TOS (p < 0.001), TAR (p = 0.007), and OSI (p = 0.001) were significantly different between the two groups. Six months after surgery, we noticed significant changes (42.28% decrease) of hsCRP (p = 0.044) and OSI (p = 0.041) (31.81% decrease), while no significant changes were observed for chemerin (p = 0.605), TNF-α (p = 0.287), NOx (p = 0.137), TOS (p = 0.158), and TAR (p = 0.563). Conclusions Our study showed no significant changes of chemerin, and except for hsCRP and OSI, no other inflammatory and nitrooxidative stress markers changed six months after surgery.

Highlights

Mounting evidence has demonstrated that excess adipose tissue is a source and a cause of chronic inflammation, oxidative stress, and adipokine dysregulation which are all interrelated and involved in development of metabolic complications [1, 2]
Regarding the mean values of chemerin (Mann– Whitney U test, Z = 1 83, p = 0 07) and TNF-α (Mann– Whitney U test, Z = 1 84, p = 0 06), we identified a tendency towards statistical significance between the two groups
The present study was designed to analyze the hypothesis that increased levels of chemerin in a group of morbidly obese (MO) patients change 6 months after sleeve gastrectomy (SG) and that these changes run in parallel with changes of other inflammatory markers such as high-sensitive C-reactive protein (hsCRP), TNF-α, and nitrooxidative stress leading to a reduction of the cardiovascular risk

Summary

Introduction

Mounting evidence has demonstrated that excess adipose tissue is a source and a cause of chronic inflammation, oxidative stress, and adipokine dysregulation which are all interrelated and involved in development of metabolic complications [1, 2]. We investigated the levels of chemerin, high-sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), and oxidative stress index (OSI) in a group of 24 MO patients submitted to SG before and six months after surgery. We noticed significant changes (42.28% decrease) of hsCRP (p = 0 044) and OSI (p = 0 041) (31.81% decrease), while no significant changes were observed for chemerin (p = 0 605), TNF-α (p = 0 287), NOx (p = 0 137), TOS (p = 0 158), and TAR (p = 0 563). Our study showed no significant changes of chemerin, and except for hsCRP and OSI, no other inflammatory and nitrooxidative stress markers changed six months after surgery

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Results

Conclusion