Abstract
In this study, we evaluated the anti-cancer property of five bark extracts and the isolates from chloroform and ethyl acetate of Annickia chlorantha by the tetrazolium salt method (MTT method). The anti-cancer activity was performed on human prostate cancer cell lines PC-3 and hormone-dependent breast cancer cell lines MCF-7. Results indicated that the two isolates displayed interesting cytotoxicity towards MCF-7 cell lines with CC50 of 3.84 CC50/mL and 4.87 CC50/mL for chloroform and ethyl acetate respectively; while the total bark extracts showed CC50 of 24.33 CC50/mL, 36.49 CC50/ mL and 73.52 CC50/mL for chloroform, ethyl acetate and methanol extracts respectively. By the other hand on PC-3, the CC50 of the isolates were higher than the one on MCF-7, more than 10 CC50/mL for both chloroform and ethyl acetate isolates and 49.14 CC50/mL, 77.33 CC50/mL, 89.38 CC50/mL and 92.37 CC50/mL, respectively for chloroform, ethyl acetate and methanol soluble extracts. From this study, we identified that the two isolates had anti-cancer properties against MCF-7 cell lines.
Highlights
Cancer is considered as an important and large family of diseases, in which abnormal cells grow and form a subset of neoplasm, with the potential to spread to other parts of the body
We are reporting for the first time the study based on anticancer properties of five crude extracts of Annickia chlorantha, from Democratic Republic of the Congo, which has been used in African traditional medicine as anti-malarial, anti-fever and for dyeing and back ache properties [12]-[14] and for two isolates obtained from the chloroform and ethyl acetate extracts of this plant
The present study revealed that treatment of MCF-7 cell lines with isolates resulted in significant inhibition of the cell proliferation
Summary
Cancer is considered as an important and large family of diseases, in which abnormal cells grow and form a subset of neoplasm, with the potential to spread to other parts of the body. This abnormal growth of cells can many times lead to death. Some phytochemicals agents from plants are used for cancer treatment, including: vincristine, taxol, vinblastine, camptothecin derivatives etc., are all over the world in clinical use. Others promising agents such as betulinic acid, flavopiridol, combretastatin, A-4-roscovitine and silvestrol are in clinical or preclinical development [10] [11]
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