Abstract
1. 1. Amoxicillin concentration in pus from odontogenic infection was assayed and the concentrations were compared with MIC (minimum inhibitory concentration) of α-hemolytic streptococci isolated from odontogenic infection. 2. 2. Measurable amoxicillin concentrations in serum and pus were found in all instances ( n = 16). 3. 3. The mean peak concentrations in serum and pus were found at identical times, 1.5 hr after administration, which were 5.92 and 0.90 μg/ml, respectively. 4. 4. The mean concentration ratio of pus/serum the at the peak time was 0.15. 5. 5. All amoxicillin concentrations in pus at the peak time exceeded the MIC for 90% of α-hemolytic streptococci (0.25 μg/ml).
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