Abstract
Studies have shown that physical activity levels can be inversely associated with high-sensitivity C-reactive protein (hs-CRP) levels. However, the amount of physical activity required to maintain normal hs-CRP levels is still a matter for speculation. To identify the amount of physical activity necessary to discriminate the hs-CRP levels in adults. Cross-sectional study at six teaching and research institutions. The study sample comprised 10,231 adults aged 35 to 74 years who were participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Receiver operating characteristic (ROC) curves were constructed to compare the amount of physical activity in two domains (leisure time and commuting) with hs-CRP levels. The sensitivity and specificity were calculated to identify the best cutoff for physical activity level that would be needed to maintain normal levels of hs-CRP (< 3 mg/l). The area under the ROC curve was only statistically significant for discriminating normal levels of hs-CRP according to the amount of physical activity when the two study domains were added together. The accumulated physical activity level of 200 minutes/week was the best cutoff for discriminating normal levels of hs-CRP in adults of both sex. Physical activity in the leisure-time and commuting domains together, of duration 200 minutes/week, was associated with normal hs-CRP values.
Highlights
Cardiovascular disease is the leading cause of death and disability worldwide and in Brazil.[1,2] Epidemiological studies conducted over the last 50 years have described risk factors for cardiovascular disease and for coronary heart disease, such as dyslipidemia, hypertension, smoking and diabetes.[3]
New risk markers such as high-sensitivity C-reactive protein levels have been highlighted over recent years as potential predictors of cardiovascular risk.[4,5] hs-CRP is an acute-phase protein produced in the liver through the primary stimulus of the interleukins IL-1 and IL-6
This study demonstrated the discriminatory power of the sum of physical activity in the two domains studied (LTPA + commuting physical activity (CPA)) for normal levels of hs-CRP in adults
Summary
Cardiovascular disease is the leading cause of death and disability worldwide and in Brazil.[1,2] Epidemiological studies conducted over the last 50 years have described risk factors for cardiovascular disease and for coronary heart disease, such as dyslipidemia, hypertension, smoking and diabetes.[3]. Studies have shown that physical activity levels can be inversely associated with high-sensitivity C-reactive protein (hs-CRP) levels. The sensitivity and specificity were calculated to identify the best cutoff for physical activity level that would be needed to maintain normal levels of hs-CRP (< 3 mg/l). RESULTS: The area under the ROC curve was only statistically significant for discriminating normal levels of hs-CRP according to the amount of physical activity when the two study domains were added together. The accumulated physical activity level of 200 minutes/week was the best cutoff for discriminating normal levels of hs-CRP in adults of both sex. CONCLUSIONS: Physical activity in the leisure-time and commuting domains together, of duration 200 minutes/week, was associated with normal hs-CRP values
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