Abstract
In undertaking investigations of the function of ascorbic acid in the skin no reference could be found in the literature concerning the amount of ascorbic acid in epidermis. Jensen and Poulsen in 1942 made an extensive study of the concentration of ascorbic acid in 181 specimens of skin obtained by punch biopsy from 72 persons. They extracted the tissue with 8% metaphosphoric acid solution TABLE I Specimen Area Cause of Amputation Ascorbic Acid, mg. per 100 gm. wet weight Epidermis Corium Whole Skin 1 2 3 4 5 6 7 8 9* 10 Breast Breast Leg Leg Breast Leg Breast Breast Breast Breast Carcinoma Carcinoma Sarcoma of bone Arterial thrombosis Carcinoma Diabetic gangrene Carcinoma Carcinoma Carcinoma Carcinoma 8.35 8.26 4.94 6.64 6.63 6.89 12.80 5.41 11.31 13.40 3.48 1.00 0.18 3.37 4.98 3.08 6.40 3.23 4.25 7.00 7.30 9.90 Negro and titrated this extract with a solution of 2,6-dichlorophenol indophenol which had been standardized with an aqueous solution of ascorbic acid of known concentration. In 95% of the specimens of normal skin they found concentrations of ascorbic acid varying from 0 to 10 mg. per 100 grams of skin (wet weight). At that time no satisfactory method was available for separating epidermis from corium without some chemical alteration (1).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
