Abstract
Metal-based nanozymes with exceptional physicochemical property and intrinsic enzymatic properties have been widely used in industrial, medical, and diagnostic fields. However, low substrate affinity results in unsatisfying catalytic kinetic and instability in complicated conditions, which significantly decreases their sensitivity and reliability. Herein, an amorphous hollow manganese silicate nanosphere (defined as AHMS) has been successfully synthesized via a facile one-step hydrothermal method and utilized in the archetype for colorimetric detection of biothiols with highsensitivity and high reliability. The experimental data demonstrates that ultrafast affinity of thesubstrate contributes to enhanced sensitivity with outstanding catalytic kinetic features(Km = 27.1 μM) and lowlimit of detection (LODGSH = 20 nM). Thedesigned sensor demonstrates a reliable applicabilityfor analysis ofbiological liquids (fetal calf serum and Staphylococcus aureus) and design of visual logic gates. Therefore, AHMS provides a promising strategy for ultrasensitive and high-reliable biosensing.
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