Abstract
Prostaglandin F 2α and E 2 concentrations in the amniotic fluid and fetal membranes of 35 patients was analysed, in order to investigate differences in prostaglandin synthesis in parous and nulliparous women, and to find whether women who subsequently required oxytocin to accelerate labour, showed any difference in intrauterine prostaglandin concentrations. Significantly less PGF 2α was detected in the amniotic fluid of women who required oxytocin, and fetal membrane PGE 2 was significantly lower in these women at delivery. Differences in PGE 2 and PGF 2α in parous and nulliparous women were less mar ed. Amniotic fluid levels of PGF 2 at Artificial Rupture of the Membranes (ARM), and the ratio of PGF 2α/PGE 2 at ARM, were prognostic for the subsequent progression of labour.
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