Abstract
Introduction: Exosomes, nanosized vesicles derived from various cellular sources, hold immense potential in modulating physiological processes and promoting tissue repair. Exosomes derived from amniotic fluid show significant promise in regenerative medicine and tissue repair. To our knowledge, there are no reported cases of reduction of chronic pain due to bone- and cartilage degeneration reported after exosome treatment. Case presentation: Three male patients, all with chronic pain and reduced physical function due to bone- or cartilage degeneration all showed a remarkable reduction in pain and increase in function after one single injection of amniotic-derived exosomes. Conclusion: These cases raise the hypothesis that amniotic-derived exosomes may be an effective intervention in the treatment of degenerative bone- and cartilage diseases. Especially in combination with other regenerative medicine interventions. Further research is required to test this theory.
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