Abstract
Summary Supplementation of human normal glial cells with NH 4 Cl led to marked effects on the metabolism of sulphated glycosaminoglycans (GAG). Sulphated GAG accumulated intracellularly in the presence of NH 4 Cl. Further, the degradation of sulphated GAG was partially inhibited. These phenomena were accompanied by an accumulation of lysosomes within the glial cells. The characteristics of NH 4 Cl-treated cells were thus similar to those displayed by cultured cells from patients with mucopolysaccharidosis.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
