Abstract
It was confirmed that chloramphenicol and chloramphenicol palmitate form NH3 adducts with combining ratios of 1 : 2 (chloramphenicol : NH3), and 1 : 2 and 1 : 1 (chloramphenicol palmitate : NH3). The thermal and physico-chemical properties of their NH3 adducts and the recovered chemicals were investigated by differential scanning calorimetry, infrared spectroscopy, X-ray diffractometry, and scanning electron microscopy. Elimination of NH3 from the adducts of chloramphenicol and chloramphenicol palmitate proceeded readily at normal temperatures and pressure to yield very fine particles of the original chemicals. Further, the effect of repeating the process of sorption and desorption of NH3 on particle size was investigated in the case of chloramphenicol palmitate by the gas adsorption method. Two or more repetitions of the process produced a significant increase in specific surface area.
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