Abstract
Calcium channel blockers are frequently used for treatment of hypertension. Studies have reported hyperpigmentation secondary to calcium channel blockers, although cases are limited and mostly related to diltiazem and nifedipine. To our knowledge, there are only two cases describing hyperpigmentation secondary to amlodipine.
Highlights
Calcium channel blockers (CCB) are a group of drugs commonly prescribed for the treatment of hypertension
While there have been several cases documenting hyperpigmentation secondary to CCBs such as nifedipine and diltiazem [3,4,5,6,7], only two cases of hyperpigmentation have been published related to amlodipine to our knowledge
We present a case linking hyperpigmentation to the calcium channel blocker amlodipine
Summary
Calcium channel blockers (CCB) are a group of drugs commonly prescribed for the treatment of hypertension. Due to their potent vasodilatory action in cardiac and vascular smooth muscle, the most common adverse reactions associated with CCBs include edema, flushing, fatigue, palpitations and headache. While there have been several cases documenting hyperpigmentation secondary to CCBs such as nifedipine and diltiazem [3,4,5,6,7], only two cases of hyperpigmentation have been published related to amlodipine to our knowledge. The inferior nasal ala showed increased hyperpigmentation compared to the year prior (Figure 2b). Figures 1: Macular slate-gray discoloration of the bilateral inferior nasal ala on patient’s right (a) and left side (b)
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