Amlodipine besylate and atorvastatin calcium tablets for hypertension and coronary heart disease complicated with carotid atherosclerosis

Abstract

Objective To study the clinical effect of amlodipine besylate and atorvastatin calcium tablets for hypertension and coronary heart disease complicated with carotid atherosclerosis. Methods 69 cases of hypertension, coronary heart disease, and carotid atherosclerosis treated at our hospital from December, 2012 to July, 2016 were selected and divided into an observation group (n=35) and a control group (n=34) by random number table method. The observation group were treated with amlodipine besylate and atorvastatin calcium tablets and the control group amlodipine. The DBP, SBP, HDL-C, LDL-C, TG, TC, NO, hs-CRP, and incidence of adverse events were compared between these two groups before and 6 weeks after treatment. Results 6 weeks after treatment, the DBP and SBP were improved more, the levels of NO and HDL-C were higher, and the levels of LDL-C, TG, hs-CRP, and TC were lower in the observation group than in the control group, with statistical differences (P < 0.05). The incidence of adverse events was 2.86% in the observation group and was 23.53% the control group, with a statistical difference (P < 0.05). Conclusions Amlodipine besylate and atorvastatin calcium tablets for hypertension and coronary heart disease complicated with carotid atherosclerosis can improve the patients’ blood pressure, inflammation status, and lipid metabolism conditions and reduce the incidence of adverse events, so it is worth being generalized. Key words: Carotid artery atherosclerosis; Amlodipine besylate and atorvastatin calcium tablets; Coronary heart disease; Hypertension