Abstract
Amlodipine is a long-acting dihydropyridine-based Ca 2+ channel blocker, developed for use on a once-daily basis. Experiments using hearts from amlodipine-pretreated rats were undertaken to further test the hypothesis that Ca 2+ channel blockers can be used as prophylactic therapy to reduce the severity of the mechanical and biochemical consequences of ischemia and reperkhsion. Amlodpine was given intravenously, 0.25 mg/kg, 5 hours before excising the hearts. Ischemia (global) was induced at 37°C for 10, 30 or 60 minutes, and was followed by reperfusion. Protection was quantitated in terms of functional recovery, adenosine triphosphate and creative phosphate retention, tissue acidosis and Ca 2+ gain. The results show that amiodipine pretreatment supplied. protection, provided that the ischemic episode did not exceed 30 minutes. The protection resulted in improved recovery of peak developed tension on reperfusion, reduced Cat+ gain, retention of tissue adenosine triphosphate and creative phosphate, and reduced acidosis.
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