Abstract
Extramedullary plasmacytoma (EMP), characterized by infiltration of malignant plasmablastic clones outside the bone marrow in absence of multiple myeloma. Accounting for approximately 4% of all plasma cell dyscrasias, it has a predilection for head and neck region.
Highlights
Plasma cell dyscrasia is an assortment of hematological malignancies arising from excessive monoclonal proliferation of neoplastic plasma cells and detection of a monoclonal immunoglobulin protein (M component)
Based on potency and various practice guidelines, amiodarone is recommended for treating arrhythmias such as conversion of atrial fibrillation (AFib) to sinus rhythm or ventricular tachycardia
We present a case of arsenic trioxide (ATO) induced AFib in a primary lumbar disc plasmacytoma diagnosed patient and amiodarone to prevent it
Summary
Plasma cell dyscrasia is an assortment of hematological malignancies arising from excessive monoclonal proliferation of neoplastic plasma cells and detection of a monoclonal immunoglobulin protein (M component). An extramedullary plasmacytoma (EMP) was diagnosed on intervertebral tumor biopsy with infiltration of at least 40% of plasma cells (Figure 1A and B). An immediate EKG pointed out atrial flutter accompanied with fast ventricular rate and on the same day chemotherapy was discontinued This time we again performed cardioversion procedures, administered intravenous amiodarone. Despite the patient during cardioversion developed embolism risk factors, he left hospital later It was almost one year since his extramedullary plasmacytoma was diagnosed, the sixth cycle of therapy we included pomalidomide. He had AFib relapse throughout the chemotherapy sessions. His back’s nodule was disappeared (Figure 5) and no tenderness was recorded
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