Abstract
The rates of activation and unitary properties of Na+-activated K+ currents, K(Na) currents have been found to vary substantially in different types of neurons. One class of K(Na) channels are encoded by the Slack gene. We have now determined that alternative RNA splicing gives rise to at least five different transcripts for Slack, one class of K channels which produce Slack channels that differ in their predicted cytoplasmic amino-termini and in their kinetic properties. Two of these, termed Slack-A channels, contain an amino-terminus domain closely resembling that of another class of K(Na) channels encoded by the Slick gene.
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