Aminobromination of β‐Nitrostyrene Derivatives with N,N‐Dibromourethane as the Aminobrominating Reagent

Abstract

AbstractA concise and efficient aminobromination reaction for β‐nitrostyrene derivatives by treatment with N,N‐dibromourethane was developed. For the β‐nitrostyrene derivatives, the aminobromination successfully proceeded at room temperature in CH3CN without catalysis or protection by an inert gas and gave products in excellent yields (80–97 %). For the β‐methyl analogs, the reaction proceeded smoothly with anhydrous K2CO3 as a catalyst under the same conditions to provide the aminobrominated products in good yields (53–78 %). A possible pathway for this electrophilic addition reaction is proposed.