Abstract
2-Aminoalkanesulfonic acids have been synthesized by a three-component alkene/SO3·DMF/acetonitrile reaction, followed by hydrolysis. Trifluoromethanesulfonic acid was added to the amino-sulfonation mixture to accelerate the reaction and prevent the competitive formation of by-products. The reported two-step procedure provided a concise and versatile approach to new analogues of the natural amino acid taurine. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
Published Version
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