Amino-modified mesoporous silica SBA-15 as bifunctional drug delivery system for cefazolin: Release profile and mineralization potential

Abstract

In this paper the amino-modified mesoporous silica (SBA-NH2) was investigated as a potential bifunctional drug delivery system for cefazolin with both prolonged drug release and mineralization properties. The primary SBA-15 was synthesized using sol-gel method and surface functionalization was carried out using post-synthesis grafting. The obtained SBA-NH2 was characterized by higher adsorption efficiency of cefazolin with drug release prolonged to 7 days compared to primary SBA-15. The amino-modified SBA-15 exhibited also mineralization potential after immersion in simulated body fluid (SBF) with delayed hydroxycarbonate apatite (HCA) formation compared to SBA-15 which did not interrupt the cefazolin release in controlled manner. A bone-mineral-mimicking layer of HCA was formed on the SBA-NH2 surface after 28 days in SBF.