Abstract

Free and protein amino acids in different regions of human brain have been investigated quantitatively by paper chromatography. Individual free amino acids were higher in grey matter than in white matter. The concentration levels of the spectrum of free amino acids varied over wide limits within each region of the brain. Protein amino acids showed a different Chromatographic pattern from free amino acids. The concentration levels of the spectrum of protein amino acids fell within narrower limits than free amino acids in each region. The range of values for the ratio protein/free amino acids varied widely in each region of the brain. Comparisons are made with animal brain amino acids. The significance of the findings is discussed.

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