Abstract
The Nim-2-adamantyloxycarbonyl (2-Adoc) group has been found to be both suitable for protection of the imidazole function of the histidine residue in peptide synthesis in terms of its stability to trifluoroacetic acid (TFA), tertiary amines and 1-hydroxybenzotriazole (HOBt), and in its reduction of the racemization rate during the coupling reaction. Nim-2-Adoc protection has also been applied successfully to the solid-phase synthesis of thyrotropin-releasing hormone which depends on tert-butoxycarbonyl (Boc)-chemistry.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Chemical Society, Perkin Transactions 1
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
