Abstract
Amide bond formation is one of the most important reactions in organic chemistry. Amides occur in a wide variety of pharmaceuticals and other biologically active compounds, including peptides and proteins. In living cells, amide bonds are formed by ribosomes in very specific circumstances, which are not possible in organic chemistry. This chapter looks at the conventional mechanism, solid-phase peptide synthesis and chemoselective amide-forming ligation before discussing some of the problems associated with these reactions and approaches towards greener reactions.
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