Amenorrhea

Abstract

Key Points Last menstrual period should be considered a vital sign and abnormalities should be investigated.Clinicians should educate girls and their caregivers about what to expect from the first menstrual period and the variation in cycles thereafter.Amenorrhea is defined as the absence of menses and can be primary or secondary.Functional hypothalamic amenorrhea is associated with stress, weight change, chronic illness, physical activity, and eating disorders. Prolonged amenorrhea can lead to low bone density caused by inadequate estrogen production.