Abstract
This study was designed to demonstrate the ameliorating effects Annona muricata (Graviola)plant extract and fullerene C60 on hematological and biochemical disorder alteration induced by intraperitoneal (i.p.) injection of carboplatin (CRP) on male rats. Five groups of adult male rats we established (n=10). Group1: animals were administered normal saline i.p. (10 ml/kg b.wt) for 40 days and served as a normal group. Group 2: rats were injected i.p. with a single dose of CRP (80 mg/kg b.wt), then received a saline solution for the remaining 40 days and served as a control group. Group 3: animals were oral administration of Annona muricata leaves extract at a dose of 200 mg/kg/day for 40 consecutive days after 24 hours of i.p. injected with a single dose of CRP (80 mg/kg b.wt.). Group 4: animals weretreated orally by fullerene C60 (4 mg/ kg b.wt.) daily for 40 daysafter 24 hours of i.p. injected a single dose of CRP (80 mg/kg b.wt.). Group 5: each rat in this group was daily oral administration of Annona muricata leaves extract at a dose of (200 mg/kg b.wt.)+ fullerene C60 (4 mg/ kg b. wt.) for 40 days after 24 hours of injected a single dose of CRP. Results obtained revealed that CRP administration in the control group (gp. 2) significantly reduced the levels of red blood cells (RBCs), haemoglobin (Hb), blood Platelets (PLTs) and PCV value, with a marked reduction in white blood cells (WBCs). Additionally, there is an elevation in serum ALT, AST, ALP, total bilirubin, creatinine and urea associated with a reduction in albumin, total protein, and uric acid. In addition, hepatic and renal thiobarbituric acid reactive substances (TBARS) levels were significantly increased by CRP administration while levels of endogenous antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were reduced. This study confirmed the risk of increased oxidative stress, hepatotoxicity and nephrotoxicity due to CRP administration. In addition, Annona muricata leaves extractand fullerene C60, clarifiedmodulatory role against the cellular damage produced by free radical-induced by CRP.
Highlights
CRP is one of platinum-set chemotherapeutic (Simon et al, 2014)
Recorded a graduated improvement as a highly significantly increased at (p
Effect of Annona muricata Leaves Extract and Fullerene C60 on Some Hematological Parameters of Rats Intoxicated with CRP: In the current study, it was detected that due to single dose of CRP treating rats, the number of RBC, WBC, PLT, Hb content, and mean values of PCV were significantly decreased, Equivalent results were stated by several authors (Hassan and Chibber, 2010 and Ashry and Elkady, 2014)
Summary
CRP is one of platinum-set chemotherapeutic (Simon et al, 2014). CRP is a block of platinum that characterizes a class of an active anticancer agent generally used to treat several types of cancer such as ovarian, head-neck, small cell lung cancer, thyroid, gastric, breast, nonHodgkin's and Hodgkin's lymphoma, multiple myeloma, and sarcomas. Which plays a significant role in CRP induced toxicity of kidney and liver. Medicinal plants are a good source of natural antioxidants believed to exert their effect by reducing the formation of the final active metabolite of the drug-induced systems or by scavenging the reactive molecular species to prevent their reaching a target site. Annona muricata is a genus of tropical fruit trees belonging to the family Annonaceae, of which there are about 119 species (Neela and Alexander, 2010). This plant contains chemical compounds that show antitumor, pesticidal, antiviral and antimicrobial effects, signifying several potentially beneficial applications. Annona muricata has therapeutic uses dropping elevated blood pressure (Sushmita et al, 2012)
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