Abstract
Inflammation affects many illnesses, like metabolic conditions, psychotic neurodegenerative disorders, and cancer. Hence, many anti-inflammatory drugs are prescribed by professionals. These drugs may have adverse effects. Many natural and plant-origin bioactive compounds have anti-inflammatory properties. In this study, the anti-inflammatory effect of tamarind leaves was evaluated using an animal model. The present research concluded that the tamarind leaf supplementation decreased cholesterol, triglycerides LDL and VLDL levels and hence possess hypolipidemic effects on rats. Tamarind leaves supplementation also showed an antioxidant effect through increasing SOD, catalase and reduced glutathione activities. Tamarind leaves supplementation also showed an anti-inflammatory effect by decreasing IL-6 and COX-1 as well as increasing IL-10 levels in serum and kidney, but no significant difference was observed in TNF-α, COX-2 and 5- LOX levels. Tamarind leaves reduce oxidative stress and inflammation by restoring the body's natural antioxidant equilibrium and controlling the production of inflammatory mediators. Thus, tamarind leaves can be used as a functional food and nutraceutical to reduce inflammation.
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