Abstract
Medicinal plants are among the important source of potential therapeutic agents for diabetes. Therapeutic use of <i>Moringa oleifera</i> leaf extract has been practiced in management of diabetes because of its potential to decrease blood glucose and lipids concentration after ingestion. This study was conducted to evaluate the ameliorative effect of <i>Moringa oleifera </i>leaf extract on streptozocin induced diabetes Wistar rats. Initially, diabetes was induced by given streptozocin (STZ) intravenously followed by the treatments with different concentration of<i> Moringa oleifera</i> aqueous leaf extract. Fasting blood glucose level was measured using Accu-Chek glucometer after 24, 48, 72 and 97 hours post treatment. There is significance difference at 0.05 in blood glucose level between the control groups and the groups that were treated with the leaf extract after administration of STZ. Hence, this plant shows high potential to be used in the management of hyperglycaemia. The need for the toxicity study to evaluate it effect in body tissues and organs is recommended. There is need to study the phytochemical constituents to identify the bioactive lead compound with ameliorative effect.
Highlights
Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both [1]
Significance difference at p>0.05 was observed between the control groups (CTR) and the groups that were induced with stz followed by the treatment with Moringa oleifera leaf extract (D+MLE) as well as the groups that were induced without treatment (DIABETIC ALONE) and the groups that were induced and treated with the standard drug glibenclamide (D+G) figure 1
Moringa oleifera leaf extract was observed to lower glucose level after established diabetes induced by Streptozocin (STZ)
Summary
Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both [1]. Several patho-physiology changes occur in pathogenesis of diabetes mellitus These include autoimmune destruction of the pancreatic β-cells with consequent insulin deficiency, abnormalities that result in resistance to insulin action, damaged to hepatic cells etc. Reductions of hepatic elevated hydroxyl proline content and myeloperoxidase activity were observrd [11] The leaf from this plant was used as good source of natural antioxidants and enhance the shelf-life of fat containing foods due to the presence of various antioxidant bioactive compounds such as ascorbic acid, flavonoids, phenolics and carotenoids and been reported to be a rich source of β-carotene, protein, vitamin C, calcium and potassium [12]. Diabetes mellitus is a metabolic condition that has been a leading cause of death in the whole world, especially among the less privileged population and rural areas due to lack of availability
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