Abstract
Ameliorative and Preventive Effects of Metformin, Nigella sativa, Punica granatum and Zingeber officinale on Bone Damage and Infections Caused by Diabetes mellitus in Animal Model
Highlights
Diabetes mellitus is a chronic metabolic condition that leads to a high plasma glucose levels[1,2,3]
In present study we examined the influence of Ginger, Nigella sativa, Punica granatum and Metformin on the prevention and treatment of bone damage and infections due to Diabetes mellitus in STZ-induced diabetes in male Wistar albino rats. 40 rats were used in the study, and it was observed that all the studied substances prevented infections and bone damage at the same time, significant increase was found in the bone volume, strength, density, and length in comparison to diabetic rats
Bone length was significantly increased in G7 (Zingiber officinale) and G8 (Nigella Sativa) versus G6 but was significantly decreased in G9 (Punica granatum) versus G7
Summary
Diabetes mellitus is a chronic metabolic condition that leads to a high plasma glucose levels[1,2,3]. Diabetes mellitus primarily results from, defect in feed mechanism leading to disordered homeostasis, defect in the secretion of insulin or defective insulin resistance adjuvant to inadequate insulin secretion. Type 2 diabetes mellitus is characterized by the inability of efficient insulin use, referred to as insulin resistance joined with an inability to secrete a ample amount of insulin to outcome the insulin resistance. It has been observed that diabetes badly affects bone health. DM is known to enhance and lengthen inflammation, that may add to enhanced bone breakdown. Diabetes mellitus escalates osteoclast synthesis in a number of conditions including periodontal disease, fracture healing and osteoporosis[4,5,6]
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