Amelioration of CFA induced arthritis in rats by buchnania lanzan

Abstract

Buchanania lanzan spreng commonly known as Char, Charoli is a tree 12-15 mt high, with straight trunk, belonging to family from Anacardiaceae. An herb known as priyal is a drug of the ayurveda and the unani system of medicine. It is known as chironji (or charoli). Buchanania lanzan plant has well-known traditional uses in ayurveda and unani system of medicine; almost all parts of the plant i.e. roots, rhizome, leaves, fruits, seeds and gum are used for the treatment of various disorders. The gum oozed from the cut-bark is used internally for treatment of intercostals pain and diarrhoea. The gum is mixed with goat`s milk for effective and curative results in intercostals pains, being analgesic. Some tribal communities of Andhra Pradesh consume a blend of the gum dissolved in cow`s milk for treating rheumatic pains. The ethnomedical use of plant in arthritis is evaluated using in vitro and in vivo (CFA induced) models. Among the pet ether, ethyl acetate, ethanol and aqueous extracts, ethanolic and aqueous extract found to exert better effect against arthritis in in-vitro models and hence only these 2 extracts at their high and low dose were evaluated for in vivo models of arthritis induced by CFA.