‎Ameliorating Effects of Herbal ‎Mixture for Dexamethasone Induced Histological Changes in Mice

Abstract

Organs of mammals are affected negatively by dexamethasone under the effect of different factors, which medicinal herbs can repair because of their unique properties as a rich source of bioactive phytochemicals that ‎could lead to the creation of new medications. Most phytochemicals derived from ‎plants are antioxidant agents that have improved health disorders. The objective of ‎the current study is to detect the action of ethanol extract of three combination herbs (Hibiscus ‎sabdariffa, Portulaca oleracea, and Eruca sativa) on the skeletal muscle liver, and testes of ‎mice affected by dexamethasone drug. Eighteen white male mice equally divided into three groups. The first group received dexamethasone ‎intramuscularly (IM) for 21 days. The second group was injected with dexamethasone IM and ‎herbs mixture extract orally after one hour for 21 days. While the third group, which served as the ‎control group, was injected with normal saline IM. The specimens were fixed and processed to ‎evaluate the histological changes. Necrosis and degeneration appeared in the ‎skeletal muscle and liver sections, while no histological changes observed in the dexamethasone-treated group's testes. We observed regeneration and repairing action in the organs studied of the herb in ‎the combination-treated group. It was concluded that a combination of herbs extract plays a significant repairing action of organs ‎affected by dexamethasone.‎