Abstract
Psoriasis is a common chronic skin condition characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation.
 In this work, psoriasis was induced by an imiquimod 5% cream, an immune response modifier that can induce psoriasis-like skin inflammation when applied topically in mice. Guggulsterone prepared as a suspension and has been orally given to mice before imiquimod application. The results of the current study showed that guggulsterone suspension can significantly reduce psoriasis area and severity index in (guggul suspension+imiquimod group as compared with both control group and (vehicle suspension+imiquimod ) group.
Highlights
Psoriasis is a common chronic skin condition characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation
Table 4: showed that there was a significant decreament in the measured psoriasis area and severity index in Psoriasis Area and Severity Index (PASI) score in group as compared to the control group
In group, the oral administration of guggulsterone produces a reduction in PASI score significantly in comparison with group
Summary
Psoriasis is a common chronic skin condition characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation. It is currently thought of as at-cell mediated type-1 autoimmune disease[1]. Psoriasis is believed to result from a complex interplay between genetics, environment, and skin barrier disruption, and immune dysfunction[2,3]. Psoriasis exists on a reasonably broad spectrum in terms of clinical manifestations and it is associated with a higher percent of morbidity and the current medications can have acute side effects. Numerous clinical studies have reported a strong relation between psoriasis and atherosclerosis, type 2 diabetes, and metabolic syndrome, together with the leading causes of mortality in the Western world[4].
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