Abstract
Psoriasis is a serious inflammatory skin disease with an etiology which is not fully understood. The disease is characterized by dark, scaly, and well-demarcated skin lesions formed by epidermal keratinocyte hyper proliferation. Inflammation of the skin caused by Imiquimod (IMQ) is the most widely accepted animal model of psoriasis. The objective of the study is to test Artemisia dracunculus (steroidal fraction of it in a concentration of 5%) possible protective effects on imiquimod-induced psoriasis in mice in its topical dosage form and to compare this effect with Clobetasol Propionate (Dermovate (R)) ointment. An ointment was prepared from the aerial parts of A. dracunculus and was applied topically to mice skin before imiquimod application. The results of the current study showed that A. dracunculus ointment could significantly reduce skin cytokines and psoriasis area and severity index in (A. dracunculus ointment + imiquimod) (Group IV) treatments compared with both control group (Group I) and (vehicle ointment + imiquimod) (Group III).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Medicinal Plants - International Journal of Phytomedicines and Related Industries
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
