AMD Drusenoid deposits “L”, Lipid type, characterization, structural analysis with multimodal imaging and morphology‐structural software

Abstract

PurposeTo study AMD drusenoid deposits “L” with multimodal imaging and morphology‐structural software and see all the input of this technique and software.Methods25 eyes of 25 patients, 8 men, 17 women, with AMD drusenoid deposits “L”, Lipid Type (soft Drusen, Drusenoid PED “L”). Deposits were evaluated by Autofluorescence, IR imaging, OCT, notably OCT en FACE (Spectralis HRA‐OCT, spectral domainOCT), and Morphology‐Structural software (M‐S software). ETDRS visual acuity (VA), complete ophthalmic examination with Fundus exam were added. Size, characteristics, number, topography of the “L” deposits, their environment above and below (particularly IS‐OS, plexiform layer, choriocapillaris structure and thickness) were evaluated, each element was studied, compared cut to cut, layer to layer and time to time. M‐S software let analyze drusenoid deposit volume and contours, let a 3D deposit reconstruction, display in 3D space, let volume, density (grey levels of deposits), structure (structural measures, texture parameters),composition (density calculation) evaluation and characterization of those “L”, lipid type depositsResultsAMD Drusenoid Deposits “L” Lipid Type (soft Drusen, Drusenoid PED) are larger, roughly uniform, dome‐shaped, dark grey, translucent, optical empty, equal and the same in all cross‐section, as lipid pearl drops, fatty, mounds of deposit under the RPE, abnormal Pigment epithelium above, but layer quite preserved. M‐S software allows lipid composition confirmation, selective lipid characterization, to better differentiate lipid and more componentsConclusionsMultimodal Imaging, Morphology‐Structural Software contribute to and improve AMD Drusenoid deposits “L”, Lipid type, study and knowledge and so AMD etiopathogeny understanding.