AMD drusenoid deposits “P”, protein‐cellular type: volume, morphology, evolution analysis with morphology‐structural software

Abstract

PurposeTo study AMD Drusenoid deposits “P” with morphology‐structural software and see all the input of this software on their morphology, evolution knowledge and understandingMethods310 eyes of 155 patients, 61 men, 94 women, with AMD Drusenoid Deposits “P”, Protein‐Cellular Type (Pseudovitellifom AMD,Cuticular drusen,Subretinal drusenoid deposits(SDD),Drusenoid PED,”P”). Deposits were evaluated by Autofluorescence, IR imaging, OCT(Spectralis HRA‐OCT,spectral domain OCT) and Morphology‐Structural software (M‐S software). ETDRS visual acuity(VA), complete ophthalmic examination with Fundus exam were added. M‐S software let: grading (semi‐automatized drusenoid deposit volume and contours analyze,3D deposit reconstruction); measurements (volume(in μm3), density(grey levels of deposits)(Statistic moments of pixel intensities: mean,median,minimum,maximum,average,standard deviation,skewness and kurtosis), structure (structural measures, texture parameters),(Haralick texture measurements for distances of 1 to 10 pixels), composition(differential density calculation). Grading, measurements(volume,density) let analyze Drusenoid deposit “P”, their evolution,4 years follow‐upResultsM‐S software allows AMD Drusenoid Deposits “P”,Protein‐Cellular Type (Pseudovitellifom AMD,Cuticular drusen,Subretinal drusenoid deposits(SDD),Drusenoid PED,”P”) analyze, follow‐up: topography,volume,density,evolution, for each cut,layer,eye,patient and patient to patient. Therefore M‐S software enable Drusenoid Deposits comparison, evolution for each patient and patient to patient. So M‐S let assay AMD progression, assess evolution Drusenoid deposits “P” to Neovascular complication and its intensity and occurrence periodConclusionsMorphology‐Structural Software contribute to and improve AMD Drusenoid deposits “P”,Protein‐Cellular type, study and knowledge and so AMD understanding.