Abstract
Many ion-selective membrane electrodes for organic cations or anions of pharmaceutical interest have been described [l-3]. However, some do not provide sufficient sensitivity and selectivity for the respective ions. This paper describes the preparation and the characterization of two types of amantadine-ion selective membrane electrodes. One of them uses dipicrylamine as the counter-ion in the electroactive material of the membrane and the other electrode uses dinonylnaphthalene sulphonic acid. Both electrodes have been used successfully for the assay of 1-adamantanamine hydrochloride in amantadine hydrochloride tablets by potentiometric titration with a solution of sodium tetraphenylboron. Amantadine (1-adamantanamine) is a well known antiviral and anti-Parkinsonian drug, in therapeutic use since 1966 [4]. Analytical methods for the assay of amantadine are based on non-aqueous titration [5], potentiometry using a tetraphenylborate electrode [6], gas-chromatography [7-91, reversed-phase high-performance liquid chromatography [lo], and spectrophotometry [ll]. The present procedure allows the determination of 4 mg of amantadine in the drug substance or in tablets without any prior separation, with an average error of less than 2.0%.
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