Abstract
Novel dipodal derivatives of an 18-membered diaza-crown ether with two diamide chains featuring methylmalonic or butylmalonic acid residues were obtained and tested as ionophores in ion-selective plasticized membrane electrodes. The objective of the study was to identify measurement conditions which ensure the most favorable performance for magnesium ion-selective electrodes. The relationship between the molar lipophilic anion salt-to-ionophore ratio and selectivity of electrodes was examined. The best result was obtained for the conventional electrode containing Mg2 ionophore. Calculated selectivity coefficients were as follows: logKMg/Ca = −2.77, logKMg/Na = −3.46 and logKMg.K = −2.24 (SSM, 1M).
Highlights
The magnesium ion is one of the four most abundant in human body fluids, and it is critical for numerous cellular and biophysical functions [1]
Compounds derived from methylmalonic and butylmalonic acid were obtained by means of synthesis in order to investigate possible direction of changes in ionophore properties displayed by this type of compound in ion-selective electrodes (ISE)
Several-step syntheses starting from commercially available diesters of methylmalonic and butylmalonic acids were used to obtain adamantyl, octadecyl, and dodecyl monoamides of these acids for further reaction with commercially available 1,10-diaza-18-crown-6 yielding five novel, dipodal tetraamide derivatives of this crown ether
Summary
The magnesium ion is one of the four most abundant in human body fluids, and it is critical for numerous cellular and biophysical functions [1]. The precise determination of magnesium ion concentration is crucial for correct diagnosis and therapies for numerous diseases [2,3]. Among the various kinds of analytical tools, spectroscopic and fluorescence methods are typical for magnesium determination [4,5], but ionic chromatography or capillary electrophoresis methods are successfully applied in biological fluids analysis [6,7]. The potentiometric methods applying ion-selective electrodes (ISE) are used for magnesium determination, because they are relatively inexpensive and do not need extensive sample preparation. The interference of calcium ions remains the major problem for magnesium selective electrodes, but it could be partially solved by use of sensor platforms [12]
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